Scientist/Senior Scientist - Protein Engineering

About This Role

This opportunity in the Protein Engineering group focuses on engineering, characterizing, and optimizing antibodies, therapeutic proteins, and alternative scaffolds. The role primarily involves antibody optimization and supporting phage display–based discovery. It suits a dedicated team player with strong technical skills in molecular biology, biochemistry, and protein engineering.

Responsibilities

• Engineer, characterize, and optimize antibodies, multispecifics, therapeutic proteins, and alternative scaffolds using rational design and library-based approaches
• Execute phage display campaigns including library construction, biopanning, clone screening, and hit identification
• Perform molecular cloning (PCR, Gibson assembly, site-directed mutagenesis, restriction digest/ligation) to support construct generation and library construction
• Develop, optimize, and execute biochemical and biophysical assays (ELISA, BLI/Octet, SPR, SDS-PAGE) to characterize engineered variants
• Analyze sequencing data to confirm construct identity and triage candidates for downstream evaluation
• Contribute to process improvement of molecular biology, display technology, and screening protocols
• Work collaboratively and communicate with project teams to achieve critical research objectives and timelines
• Maintain diligent, detailed, and well-organized records including electronic notebooks, laboratory information management systems, presentations, and reports

Requirements

• Bachelor’s or Master’s degree in Biochemistry, Molecular Biology, Protein Engineering, Biotechnology, Cell Biology, or a related field with a minimum of 3+ years of relevant laboratory experience

Nice to have:

• Demonstrated hands-on experience with molecular biology and cloning techniques (PCR, Gibson assembly, restriction digest/ligation, site-directed mutagenesis, bacterial transformation)
• Experience with phage display technology; experience with antibody (scFv, Fab) or single-domain antibody libraries is preferred
• Experience with protein or antibody engineering and optimization approaches
• Proficient in ELISA and binding assay techniques; experience with BLI (Octet) or SPR (Biacore) is desirable
• Knowledge of protein structure and structure-activity relationships
• Knowledge/experience in cell culture and cell-based functional assays
• Experience working with automation platforms
• Computational skills such as Python or R for data analysis, scripting, or bioinformatics workflows
• Familiarity with next-generation sequencing (NGS) data in the context of antibody discovery or directed evolution
• Effective interpersonal, written, and oral communication skills