About This Role
This role in Structural Biology involves helping discovery teams address challenging mechanistic questions by developing practical structural biology strategies. The position enables high-quality structural analysis and delivers insights that support therapeutic program decisions, offering a unique opportunity to combine hands-on structural biology with technology innovation in support of biologics and small-molecule drug discovery across multiple therapeutic areas.
Responsibilities
- Partner with discovery teams to evaluate samples, define structural biology strategies, and develop fit-for-purpose experimental plans
- Perform and guide cryo-sample preparation, grid optimization, screening, data collection, image processing, model building, refinement, and structural interpretation
- Deliver high-quality structural insights that inform mechanism of action, molecular design, and therapeutic decision-making
- Develop scalable, reproducible CryoEM workflows that improve throughput, robustness, and data quality
- Collaborate across Structural Biology, Protein Sciences, Therapeutic Discovery, Protein Engineering, Computational Biology, Medicinal Chemistry, Automation, Molecular Characterization, and therapeutic area teams
- Coordinate activities across internal facilities, external collaborators, and instrument vendors to maximize platform performance
- Evaluate and implement emerging technologies—including automation and AI-enabled tools—to improve data collection, analysis, and workflow efficiency
- Apply complementary structural biology approaches, including X-ray crystallography, MicroED, electron tomography, and integrative structural biology, where appropriate to address scientific questions
- Support and/or lead CryoEM platform activities at the South San Francisco site, including operation of the 200 kV Glacios 2 and user support for the 300 kV Titan Krios
- Contribute to scientific innovation through technology development, publications, presentations, and knowledge sharing
Requirements
- Doctorate degree PhD in Structural Biology, Biochemistry, Biophysics, or a related field
- OR PharmD
- OR MD [and relevant post-doc where applicable]
- OR Master’s degree and 3 years of Structural Biology experience
- OR Bachelor’s degree and 5 years of Structural Biology experience
Nice to have:
- Experience with X-ray crystallography, MicroED, electron tomography, or integrative structural biology
- Experience supporting structure-based drug discovery in an industry setting
- Experience studying membrane proteins, antibodies, multispecifics, GPCRs, or other challenging therapeutic targets
- Experience developing new methodologies that improve throughput, reproducibility, or success rates
- Familiarity with automated data collection software such as EPU
- Experience mentoring scientists or training CryoEM users
- Record of scientific publications, presentations, or technology innovation
- Passion for collaborative science and continuous improvement
- Experience scripting/coding with Python and/or other programming languages
- Experience operating Glacios, Titan Krios, or equivalent high-end CryoEM instrumentation
Benefits
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible
Important Details
- Application deadline: Amgen does not have an application deadline for this position; applications will be accepted until a sufficient number are received or a candidate is selected
About the Company
Amgen has helped pioneer the world of biotech since 1980 in the fight against serious diseases. With a focus on four therapeutic areas – Oncology, Inflammation, General Medicine, and Rare Disease – it reaches millions of patients each year and is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions.
