Scientist, Research Scientist, Biotech Research

About This Role

This contract position supports the discovery and development of in vivo CAR-T cell therapies for autoimmune indications and other malignancies within the Immunology & Translational Biology Research organization. The individual will design and execute a broad range of in vivo and ex vivo experimental workflows, interpret results, maintain rigorous records, and contribute scientific judgment to assay and protocol improvement. The role suits a technically skilled, highly organized, and intellectually curious scientist who can operate independently on complex problems while collaborating effectively across cross-functional teams.

Responsibilities

• Execute mouse studies supporting in vivo CAR-T programs, including organ harvest, tissue dissociation, and downstream processing of mouse organs, cell line maintenance, human PBClients, and NHP samples
• Design, optimize, and execute multiparameter (10+ color) flow cytometry panels for immunophenotyping and functional readouts
• Perform data analysis using Flow Jo and present findings to project teams and cross-functional stakeholders
• Design and perform lipid nanoparticle (LNP)-mediated transfection experiments to support in vivo delivery platform development
• Evaluate potency of formulated tLNPs using cell-based assays and propose protocol refinements
• Maintain and activate primary human T and PBClient cell cultures
• Design co-culture systems and functional assays to assess lymphocyte biology and Cliented killing efficacy aProductst specific Clients
• Execute flow cytometry-based and Incucyte live-cell imaging functional assays to assess cell health, proliferation, cytotoxicity, and engagement
• Maintain complete, contemporaneous, accurate, and audit-ready experimental records in Benchling, including ELNs, protocols, results, and reagent inventory
• Follow established SOPs with strict attention to detail while proactively identifying discrepancies, deviations, or opportunities for optimization and escalating or resolving them appropriately
• Interface with partner teams (e.g., CClient) to coordinate experiments, share data, and provide technical support including hands-on training for flow cytometry or assay execution
• Manage scheduling of complex multi-step experiments, reagent ordering, biosample coordination, and equipment bookings to ensure uninterrupted research operations
• Operate under limited supervision, designing and executing the next logical step in a series of related experiments while demonstrating independence on complex, sometimes ambiguous problems
• Deliver high-quality data with consistency and reproducibility, based on interpretation of prior results
• Develop new or alternative protocols and troubleshoot routine problems independently
• Make decisions that impact the entire work group/project team, choosing between multiple options to resolve complex problems