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About This Role
This Scientist position supports the development of novel biologic therapeutics. The role is suited to an experienced BS- or MS-level scientist with expertise in flow cytometry, mammalian cell culture, cell-based assays, and human biological samples. The Scientist will design and execute experiments, analyze and interpret data, maintain accurate records, and communicate findings to colleagues and company leadership.
Responsibilities
Design, execute, analyze, and document cell-based and biochemical experiments supporting therapeutic development
Perform multiparameter flow cytometry, including sample preparation, staining, acquisition, gating, and analysis using Flow Jo
Maintain and manipulate mammalian cell lines using rigorous sterile/aseptic technique
Conduct experiments with human biological samples, including primary cells, blood-derived materials, serum, and plasma
Develop and perform cell-based bioassays, including viability, cytotoxicity, and cell-death assays
Perform ELISA and other plate-based assays, including luminescence-based readouts
Measure cytokines and analyze cytokine-response data
Perform basic microscopy and imaging
Support characterization of biologic therapeutics and mechanism-of-action studies
Organize, graph, analyze, and interpret experimental datasets using appropriate statistical and graphical methods
Use productivity and AI-enabled tools, including ChatGPT, appropriately for research, data organization, literature analysis, and communication
Maintain complete, accurate, and traceable laboratory records
Prepare experimental summaries, figures, presentations, and reports
Present results and conclusions clearly to scientists and company management
Collaborate with internal scientists and external research partners
Contribute to experimental planning, troubleshooting, assay optimization, and method development
Requirements
BS or MS degree in biology, immunology, biochemistry, molecular biology, biotechnology, biomedical sciences, or a related field
Approximately 4+ years of relevant laboratory experience with a BS or 2+ years with an MS; equivalent combinations of education and experience may be considered
Hands-on experience with flow cytometry and Flow Jo
Strong experience with mammalian tissue culture and cell lines
Experience working with human biological samples
Strong sterile/aseptic technique
Experience with cell-based assays, ELISA or similar immunoassays, and quantitative biological experiments
Experience analyzing, graphing, interpreting, and managing experimental data
Ability to execute experiments independently and troubleshoot technical problems
Strong organizational, communication, and data-integrity skills
Ability to present scientific results clearly to laboratory colleagues and company management
Ability to work independently and collaboratively
Nice to have:
Complement biology or functional complement assays
Cytokine or multiplex cytokine analysis
Immuno-oncology
Biologic therapeutics, including antibodies, antibody-derived molecules, fusion proteins, or other protein therapeutics
Primary human cell, serum-based, or plasma-based functional assays
Cytotoxicity and cell-death assays
Luminescence-based assays
Benefits
Company-paid health insurance
Equity participation
Comprehensive employee benefits
About the Company
Xen Immune Therapeutics, Inc. is a biotechnology company focused on developing novel biologic therapeutics.
