Principal Clinical Scientist (AI Training)

About This Role

This Principal Clinical Scientist role focuses on bringing senior-level rigor to AI-driven research workflows, ensuring that clinical data used for next-generation AI systems meets the standards expected in real-world regulatory submissions. It involves shaping how AI understands, evaluates, and reasons about medical evidence, leveraging years of clinical trial expertise.

Responsibilities

• Design and review clinical trial protocols used to generate high-quality, regulatory-grade datasets for AI training
• Interpret and audit clinical trial results for accuracy, consistency, and alignment with regulatory standards
• Evaluate AI-generated clinical analyses for scientific soundness and compliance with FDA, EMA, or equivalent agency expectations
• Provide expert, structured feedback that directly improves how AI models reason about clinical trial data, outcomes, and evidence
• Work independently and asynchronously on your own schedule

Requirements

• Senior-level experience designing clinical trial protocols intended for regulatory submission
• Deep expertise interpreting clinical data for regulatory agencies such as the FDA, EMA, or equivalent
• Strong background in clinical research methodology, biostatistics, or translational science
• Naturally rigorous and detail-oriented, holding AI outputs to the same standards applied to a real submission
• Clear and confident communicator who can translate complex clinical concepts into actionable feedback

Nice to have:

• Prior experience with data annotation, data quality review, or AI evaluation systems
• Background in pharmacovigilance, medical affairs, or clinical operations
• Familiarity with AI tools or content evaluation workflows
• Experience working across multiple therapeutic areas or regulatory jurisdictions

Benefits

• Work directly on frontier AI systems that are reshaping clinical and biomedical research
• Influence how AI understands, evaluates, and applies real-world clinical evidence
• Fully remote and flexible work, when and where it suits you
• Freelance autonomy with the structure of meaningful, expert-level work
• Collaborate with world-leading AI research teams and labs on high-impact projects
• Potential for ongoing work and contract extension as new projects launch

Important Details

• Schedule: 10–40 hours per week
• Contract: hourly

About the Company

Alignerr is a company that offers hourly contracts for clinical scientists.