Director, Pharmacokinetics

About This Role

Leading a team of scientists in the Drug Metabolism and Pharmacokinetics (DMPK) group is the core of this director role. The team primarily supports discovery programs across various modalities and therapeutic areas, enabling strategic decisions from lead selection through FIH. This position requires a focus on talent development and scientific creativity, guiding the team on the design, implementation, and interpretation of in silico, in vitro, and in vivo studies necessary to influence decisions in drug discovery and development.

Responsibilities

• Provide strategic, scientific, and operational leadership for a group of scientists responsible for support through experimentation and project representation on discovery teams
• Actively work with staff to encourage and facilitate their career development
• Collaborate with internal stakeholders to ensure the timely delivery of quality data and documentation
• Collaborate with members of the DMPK organization and PDMB at large to support the advancement of scientific and strategic initiatives
• Set future strategy and facilitate/implement new technologies in the organization
• Provide scientific oversight of programs supported by staff in the group and thorough and timely review of internal and external documents prepared by team members

Requirements

• PhD in chemistry, Pharmaceutical Sciences, Pharmacology, Biomedical Engineering, Biochemistry, or related field with 8+ years of experience supporting drug discovery in the Pharmaceutical Industry
• MSci degree with 12+ years relevant industry experience will be considered
• Experienced in providing DMPK support in drug discovery programs, including assessment of tractability, dose and PK predictions, drug metabolism, assessment of drug interaction risk and communicating analyses and recommendations to interdisciplinary teams and management
• Experienced in integrating preclinical ADME, PK, and pharmacology data to enable translational PK/PD modeling and simulation to support dose selection, design of PK/PD and safety assessment studies, and dose justifications for preclinical and clinical studies
• Knowledge of cutting-edge in silico approaches to inform decision making related to the characterization of metabolism, drug interactions, exposure-response relationships and variability
• Knowledge of modern instrumentation in support of DMPK workflows
• Strong leadership, interpersonal, communication, problem solving, and collaboration skills along with strength in delivering results on firm deadlines
• At least 3 years’ experience with management or supervision of staff
• Strong aptitude for and previous experience in managing scientific teams and attracting, developing, and retaining talent
• Excellent verbal and written communications skills and an ability to excel in a team-based environment