This highly visible role operates at the center of ITF Therapeutics, serving as a strategic thought partner to the President and an integrator across the leadership team. The Chief of Staff will help shape enterprise priorities, improve decision-making, translate strategy into execution, and evolve the operating model as the company scales into a rare disease portfolio company. The role requires strength in strategy, execution, and organizational savvy, and the successful candidate will be comfortable framing ambiguous problems, challenging senior leaders, navigating a global/local matrix, and moving fluidly between strategic questions and hands-on execution.
Responsibilities
Serve as a trusted thought partner and sounding board to the President, bringing an independent point of view and helping frame the most important strategic and operating questions facing the business
Identify, structure, and drive resolution of complex or ambiguous enterprise issues, developing options, trade-offs, and recommendations to support timely decision-making
Prepare the President for high stakes internal and external moments, including Board meetings, leadership discussions, and organizational communications
Partner with the President on enterprise communications, helping translate strategy, decisions and priorities into clear narratives for employees, leadership, Board and global stakeholders
Model company values and champion a culture of transparency, accountability, and patient centered decision-making
Work closely with Group CEO chief of staff to coordinate key business processes and keep abreast of key business issues and shepherd our organizations as needed to address key opportunities and issues
Own the design and execution of ITF's planning cadences, including long-range planning, annual strategic planning, and the Annual Operating Plan
Lead enterprise goal setting, translating strategy into a focused set of priorities that the leadership team can commit to and the organization can execute
Ensure functional plans align to enterprise priorities, surfacing gaps, dependencies, and conflicts early
Partner with finance and functional leaders to integrate strategic priorities, resource requirements and financial constraints into enterprise planning; surface competing demands and trade-offs for leadership team decision-making and ensure agreed resource decisions are reflected in operating plans
Own the enterprise business performance framework and review cadence, partnering with business and functional leaders to define the critical measures of performance and ensure consistent, decision-useful reporting
Lead high-priority enterprise initiatives where ownership spans functions, significant ambiguity exists or additional enterprise leadership is required
Structure complex cross-functional work into clear objectives, workplans, decisions, dependencies, and accountabilities, and drive organizational execution through completion
Millions of jobs, with real people getting hired every day
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Identify where ways of working break down or are inefficient as the company scales and drive solutions, coordinating with Group CEO chief of staff as needed where processes extend beyond the US environment
Establish permanent ownership and operating mechanisms for initiatives once they are sufficiently mature to transition into the organization
Own the leadership team operating rhythm, including agendas, pre-reads, facilitation, decision capture, and follow-through
Design and evolve the enterprise governance model, defining which forums exist, what each is accountable for, what each decides, who participates and how issues escalate
Prepare the President and leadership team for Board and Joint Steering Committee meetings, owning the materials, the narrative, and pre-alignment with stakeholders
Ensure leadership forums are decision-oriented, with clear decision rights, high-quality pre-work, recommendations + follow through
Lead leadership team offsites end to end, from objectives and design through facilitation and outputs
Establish and maintain the standards, templates, and operating mechanisms the enterprise uses, simplifying or retiring them when they no longer add value
Partner with the President and leadership team to continually evolve the operating model, clarifying roles, interfaces, decision rights and accountabilities as the organization and portfolio grow
Serve as a key operating link between ITF Therapeutics and Italfarmaco, driving alignment across US & corporate priorities, planning, governance, reporting and decision-making
Represent the President, as appropriate, with the leadership team, functional leaders, and external stakeholders, carrying intent accurately including when the message is difficult
Build trusted relationships across functions and facilitate alignment among stakeholders with different priorities, perspectives, or incentives
Connect work across functions without displacing functional accountability, helping leaders resolve dependencies and make decisions with an enterprise rather than purely functional perspective
Requirements
Bachelor's degree
12+ years of relevant experience in biotechnology/pharmaceuticals, management consulting, strategy, business operations, program/portfolio leadership or related roles, including significant experience operating with senior executives
Demonstrated experience operating at the executive and Board level
Track record designing and running planning and governance processes in a scaling organization
Exceptional executive communication skills, including executive level writing and the ability to produce Board ready material independently
Strong analytical and strategic thinking skills with the ability to simplify complexity
Demonstrated ability to influence and collaborate across diverse teams without formal authority
Passion for rare disease innovation and patient impact
Nice to have:
Advanced degree in business, life sciences or related field (MBA, PharmD, PhD, MPH or equivalent)
Experience operating within a global matrix, ideally with a non-US parent company or global function
Commercial stage pharma experience, including product launch
Prior Chief of Staff, business operations, or portfolio management experience
Management consulting experience
Important Details
Reports To: President
About the Company
ITF Therapeutics US is scaling into a rare disease portfolio company that makes a positive contribution to a range of patient communities. The company operates at the center of ITF Therapeutics and serves as a key operating link between ITF Therapeutics and Italfarmaco.
ITF Therapeutics is the US-based rare disease division of Italfarmaco S.p.A.
